Will Hill pounced on Cardinals +6.5, advising readers to wait for a possible +7. Arizona’s five defeats have come by a combined 13 points and they actually sport a positive point differential. Hill wants to sell high on Seattle after its prime-time blowout of Washington and likes what he saw from rookie edge Walter Nolen, who notched two sacks in his debut Monday night.
Tafur grabbed Arizona +6.5, reminding readers the first meeting was decided by a last-second Seahawks field goal. Even with Kyler Murray under a 'soft benching,' Arizona’s run defense has stiffened, and Tafur expects the unit to slow Seattle enough for another one-score game.
Gennaro Filice raved about the "well-oiled" Seattle passing game, noting Jaxon Smith-Njigba’s immediate connection with Sam Darnold and the acquisition of speedster Rashid Shaheed to stretch defenses. Facing an Arizona secondary that ranks in the bottom half versus wide receivers and allows every game to stay within one score, Filice expects Smith-Njigba to continue leading the Seahawks in targets. He recommends stacking JSN in best-ball portfolios and mid-tier DFS builds while still backing Seattle ‑6.5.
Anthony Dabbundo played the Cardinals-Seahawks under 45.5 (–110). He acknowledged Seattle’s No. 2 explosive-play rate but argued the market now prices the Seahawks like a top-tier contender. Jonathan Gannon’s defense deploys light boxes meant to cap big gains, and the secondary is healthier with Garrett Williams back and rookie Will Johnson available after missing the Week 4 meeting. Seattle’s own defense grades out as Super Bowl–caliber and rarely faces negative game scripts. Arizona, meanwhile, has not lost by more than four points all season, generally keeping games slow. Dabbundo expects both offenses to struggle to generate chunk plays in the divisional rematch, making the under his preferred angle.
MacMillan argued Seattle deserves more respect, pointing to a No.1 overall DVOA ranking (4th offense, 2nd defense, 1st special teams) and league-best +1.6 Net Yards per Play. With Arizona bottom-10 in most metrics, he grabbed Seahawks ‑7 at ‑105.
