Burrell snapped up San Francisco +4.5, leaning on a monster rivalry trend—underdogs have covered 13 of the last 14 Rams-Niners clashes and San Francisco already won 26-23 in L.A. two months ago. Quarterback is unsettled (Brock Purdy or, per reports, Mac Jones), yet Burrell pointed out Jones just went 19-of-24 for 235 yards and two TDs while Christian McCaffrey erupted for 173 scrimmage yards. With the Week 10 total sitting at 49.5 (second-highest on the slate), he expects Kyle Shanahan’s offense to keep pace against a Rams secondary giving up chunk plays to quick-separation wideouts—exactly the skill set Brandon Aiyuk and Deebo Samuel provide. Even with defensive injuries, the 49ers’ revamped pass rush has held opponents to a 34 % pressure-to-sack conversion rate over the last three games. Burrell concedes the Rams deserve to be chalk on the road, but not by more than a field goal given these matchup edges and the underdog dominance in the series.

Will Hill locked in Christian McCaffrey Over 51.5 receiving yards, calling it one of the best bets in football this season. The dual-threat back has cleared this number in eight of nine games, averaging 6.9 targets and 61.7 receiving yards per contest. With the Rams ranking 30th in DVOA against running backs in the passing game, Hill thinks the line remains two catches too low.

Backing Los Angeles -4, Tafur emphasized Sean McVay’s revenge angle after last month’s loss and a juicy schematic edge: Matthew Stafford went 5-of-6 for 33 yards and 2 TD when blitzed in the prior meeting, and his nine TD passes versus the blitz over the last two games are the most in any two-game stretch since 2016. Add Kyren Williams’ receiving mismatch that previously baffled San Francisco, and Tafur expects the Rams to flip the script.

Backing Los Angeles -4, Tafur emphasized Sean McVay’s revenge angle after last month’s loss and a juicy schematic edge: Matthew Stafford went 5-of-6 for 33 yards and 2 TD when blitzed in the prior meeting, and his nine TD passes versus the blitz over the last two games are the most in any two-game stretch since 2016. Add Kyren Williams’ receiving mismatch that previously baffled San Francisco, and Tafur expects the Rams to flip the script.

Tafur laid the four with L.A., stressing that Sean McVay has had this rematch circled since last month’s loss. The 49ers had no answer for Kyren Williams as a receiver then, and Matthew Stafford was 5-of-6 for 33 yards and two TDs when blitzed in that contest. Stafford has followed up by throwing nine TDs versus the blitz over his last two games—the most in a two-game span since 2016—so Tafur expects the Rams to punish San Francisco’s pressure looks and secure revenge.

Kelly passed along the SportsLine model’s call that the 49ers cover the +3.5 spread in a majority of simulations. San Francisco is 8-4 ATS in the last 12 meetings with Los Angeles and already won outright as 8.5-point underdogs in Week 5. The Niners just beat the Giants by double digits on the road with Mac Jones under center, and Christian McCaffrey leads the league with 1,222 yards from scrimmage after posting his record-setting 16th game with both a rushing and receiving TD. The model also fades a Rams team that has been truly tested on the road only once—losing in Philadelphia—and owns the NFL’s worst field-goal percentage, third-worst extra-point rate, and bottom-10 punt-return coverage. Those hidden-yardage and reliability edges drive the projection for San Francisco to cash the ticket.

MacMillan faded San Francisco’s cosmetic record, noting the 49ers sit 15th in Net Yards per Play (-0.1), 15th in DVOA and 22nd in opponent EPA. Meanwhile the Rams are 2nd in total DVOA (3rd offense, 5th defense) and the only club top-6 in both EPA per play and opponent EPA. He laid ‑3.5 with L.A. at ‑105.