JD Bets strongly advises against betting Sean Burke's strikeout prop versus Minnesota. He cites Burke's very limited sample size (only 19 innings pitched last season) as insufficient data for confidently predicting his performance. Additionally, JD emphasizes that Minnesota historically favored hitting against right-handed pitchers last season, potentially making it a tough spot for Burke to pile up strikeouts with confidence. Due to these factors and Burke’s relative unknown quality, JD sees this prop as too uncertain and recommends a clear avoid.

Eric Lindquist advised betting against Chicago White Sox starter Jameson in the first five innings against the Oakland Athletics. Jameson had extremely poor metrics from his first outing of the season, notably a .685 expected slugging, .445 xwOBA, a troubling 14.3% barrel rate, and an alarming 8.63 expected ERA. Lindquist emphasized the value in backing starter Jeffrey Springs for Oakland to exploit Jameson's struggles, strongly recommending a first-five innings wager despite slightly less advantageous odds compared to a full-game line due to bullpen uncertainties.

Eric Lindquist highlighted Sean Burke of the White Sox as someone to bet against due to strongly negative underlying metrics in his first start. Burke allowed a troubling .683 expected slugging percentage and failed to induce meaningful swing and misses over 18 batted ball events, exposing significant struggles and vulnerability to powerful hitters entering his upcoming start against Minnesota, suggesting betting on opposing hitters.

Eric Lindquist recommended betting on Byron Buxton to hit a home run versus Sean Burke, highlighting Burke's troubling metrics from his first start. Specifically, Burke has allowed a .683 expected slugging across 18 batted ball events, indicating he's generating very little swing and miss and is vulnerable to power hitters. Lindquist pointed out that Buxton is projecting nicely at odds better than +340, implying a good betting opportunity given Burke's current form.

Bettor Mark identified possible value betting on the Chicago White Sox as significant underdogs (+158 moneyline) against the Twins due to Minnesota's offensive struggles early this season. Sean Burke's impressive first start (6 innings, 3 hits, 0.50 WHIP, 6 strikeouts against the Angels) enhances the case. The Twins have struggled to hit effectively and Mark indicated this creates a good opportunity to wager on White Sox in an underdog role, either moneyline or run line (+1.5 runs, -111 odds), as they could take advantage of the Twins' current offensive woes.

Drew Martin strongly recommended betting the White Sox at a significant home underdog price of +158 against Minnesota, citing several reasons. He noted White Sox starter Sean Burke had a six-inning shutout performance against the Angels on Opening Day, allowing only three hits. Conversely, Twins starter Pablo Lopez struggled against St. Louis in the opener (eight hits, four earned runs), and had two mediocre outings against the White Sox the previous year. Drew emphasized the Twins' current offensive struggles, pointing out they have the worst team OPS in MLB. With a relatively low game total around seven runs and Minnesota as -180 favorites, Drew believes the market setup strongly favors backing underdog Chicago, especially given their superior bullpen performance early on, boasting a 30% strikeout rate.

Brian Howard recommended a player prop on Andrew Vaughn achieving two or more total bases against the Twins pitcher Simeon Woods Richardson. He cited Vaughn’s strength in making consistent contact without striking out frequently, noting he's been streaky historically and appears to be seeing the ball well right now. Though Vaughn hasn't yet become the elite hitter some have predicted, Howard highlighted his recent strong form and expects that momentum to continue. He suggested bettors can likely still find a plus number, making this attractive among other uncertain outcomes in a tough-to-call matchup.

Eric Pathi strongly recommended an "auto chase" betting strategy for betting MLB underdogs coming off big upset wins, specifically referencing the White Sox. He explained that betting underdogs after they win outright as dogs tends to be profitable due to public sentiment driving bettors to blindly back favored teams like the Twins, assuming they cannot lose consecutive games. He advised strongly against typical pitcher-focused analysis (ERAs and starter names) unless wagering specifically on the first five innings. Instead, Pathi asserted there is significant value in betting the White Sox again following their commanding upset 9-0 victory as substantial +200 underdogs against Minnesota, noting the Twins being large favorites the following day (-180) only adds to the betting value.

Guy Boston advises betting the under on the White Sox team total (currently set at 3.5) or the first five innings total under against the Twins. Despite scoring 8 runs on opening day, the White Sox offense looked weak afterward, scoring zero and two runs in subsequent games. Historical data supports this stance as Minnesota pitcher Chris Paddack boasts strong numbers against White Sox hitters—a 35% K rate and .154 batting average against in limited matchups. Guy Boston also mentions Paddack's projected earned runs under (1.5) could be another angle, given his dominant metrics despite allowing two runs against White Sox last season. Overall, fading Chicago's weak run production stands out as the actionable recommendation here.

Brad Francis tags the Twins run line against the White Sox as his best bet of the day, noting that Chicago has failed to cover the run line at home against the AL Central in eight straight games dating back to last year. Furthermore, the Twins come into this matchup having had an unexpectedly rough series against the Cardinals. Brad strongly believes Minnesota is a better team than their recent performances suggest, anticipating they'll channel their frustration into a commanding victory against the White Sox, making the Twins run line his top confidence pick.

Eric Lindquist expressed concerns over backing the Twins lineup in their matchup against the White Sox. Despite Martin Perez's struggles last year (353 X-WOBA, 8.6% barrel percentage), Lindquist hesitated to bet Minnesota on the run line due to the Twins' recent offensive struggles against St. Louis, describing the lineup as 'sputtering.' He noted Minnesota's inconsistent performances at the plate, stressing the need for caution until their offense finds its rhythm this season.

Just a Bet Outside highlighted that Carlos Correa has a strong hitting matchup against Martin Perez, going 9-for-29 (.310) with three home runs in previous at-bats. Correa's past success against Perez suggests he could perform well again today, making him a notable option for DFS lineups or betting on hitting props.