Prisco predicted a heavy Christian McCaffrey game script in the desert, noting that Mac Jones leans on high-percentage throws and Arizona just allowed 42 points a week ago. McCaffrey has averaged 25.4 touches in San Francisco wins this year, and Prisco expects Kyle Shanahan to surpass that mark Sunday, feeding him as both a between-the-tackles runner and safety-valve receiver against linebackers surrendering 7.6 yards per target. He forecasted a 30-24 49ers win and labeled McCaffrey the slate’s safest high-priced DFS anchor.

Dustin Saracini backed George Kittle at +140 to score, pointing to 23 targets over the last three games and a perfect 100% catch rate inside the 20. The 32-year-old has already found the end zone in three of five appearances this season. Saracini called Arizona a "dumpster fire," highlighting that the Cardinals have given up almost 30 points per game across the past month. With Kittle’s red-zone efficiency meeting a defense in free fall, Saracini believes the tight end finds pay dirt again.

Rohit Ponnaiya advised playing Under 5.5 receptions on Christian McCaffrey against Arizona. The Cardinals allow just 3.9 catches per game to running backs (eighth-fewest). More importantly, quarterback Brock Purdy and wideout Ricky Pearsall return after six-week absences. Ponnaiya noted that Purdy attacks downfield more often than backup Mac Jones, and Pearsall ranks 12th in yards per route run, joining Jauan Jennings, George Kittle, and Kendrick Bourne to give San Francisco a deep arsenal. With so many mouths to feed, Ponnaiya expects McCaffrey’s target share to dip, making six catches an uphill climb.

Dobish played Christian McCaffrey Over 127.5 rushing-plus-receiving yards at -115 and 150+ at +210. In the first meeting with Arizona he logged 140 total yards despite a 16-15 defensive slog, one of six games in which he has topped 127.5. McCaffrey leads the league with 24.9 touches and 131.8 scrimmage yards per game and sits first among backs in yards after contact on receptions (153). Arizona grades out as the NFL’s worst tackling defense per PFF, a flaw Dobish believes McCaffrey can exploit for chunk gains. Although the Cardinals are 15th in yards per play allowed (5.3), missed tackles should push CMC well beyond his posted line and make the 150+ alternate viable.

Scott Kellen laid the 3 with San Francisco, citing the return of quarterback Brock Purdy and receiver Ricky Pearsall against a Cardinals squad missing wideout Marvin Harrison. While the 49ers still have defensive holes, their passing attack has been efficient, and Arizona’s offense continues to sputter. Kellen forecasted 28-21 Niners.

Everett rode with Arizona +3, explaining that injuries to Fred Warner and Nick Bosa have strained San Francisco’s defense over the past three weeks. The 3-6 Cardinals have moved the ball consistently with Jacoby Brissett under center. If they avoid turnovers, Everett believes they can cover—or even upset—a 49ers team that is 3-4 since its 3-0 start.

MacMillan grabbed the full +3 on Arizona, arguing San Francisco has slid into pure mediocrity—15th in both Net Yards per Play and DVOA. More alarming, the Niners’ defense is 26th in opponent EPA and 30th in success rate, with only Dallas and Cincinnati worse on a per-play basis. With injuries piling up and confidence wavering after a loss to the Rams, MacMillan sees no reason the crumbling Niners should be laying a field goal on the road in an NFC West dogfight.