Taking the Bears as slight home dogs, Prisco expects offensive guru Ben Johnson to unlock Caleb Williams while J.J. McCarthy faces the typical road-start jitters. He projected a 27-21 Chicago win, framing it as a small upset but logical play given Williams’ familiarity with Johnson’s scheme and the Soldier Field environment.

Prisco laid the single point with Buffalo, pointing out the Bills already eliminated Baltimore in last year’s playoffs. He acknowledged Lamar Jackson’s revenge angle but argued a raucous Orchard Park night crowd plus Josh Allen’s big-game track record tilt the 34-31 decision Bills’ way. With such a short line, he advised bettors to ride the home side rather than overthink it.

Prisco laid three with L.A., downplaying Matthew Stafford’s limited summer by focusing on Houston’s still-porous offensive line. He noted C.J. Stroud is trying to rebound from last year’s slump but will see constant heat from Aaron Donald and friends, leading to a 23-17 Rams win that cashes both the spread and under tickets.

Prisco laid 2.5 with Green Bay, calling the addition of Micah Parsons a swing factor even if the edge rusher skipped camp. He expects new coordinators on both Lion units to create early miscommunication, allowing Jordan Love to guide a 35-30 victory at Lambeau. With points likely, he advised grabbing the Packers before the line moves to a full three.

Prisco laid 2.5 with San Francisco, reminding readers the Niners have won seven of the last eight in the series and now get Christian McCaffrey and Trent Williams back healthy. Seattle turns to Sam Darnold in his first start for the franchise, a matchup Prisco believes Kyle Shanahan’s defense can exploit even in the loud Lumen Field environment. He projected a 23-17 49ers victory.

Prisco laid 7.5 with Denver, fading Tennessee rookie Cameron Ward in his first NFL start at altitude against "one of the league’s best defenses." He expects Bo Nix to capitalize on short fields and trusts Vance Joseph’s group to smother Ward, calling for a 26-13 Broncos win that justifies the large spread.

Laying six with Washington, Prisco noted Jayden Daniels enters year two after an "impressive rookie showing" while Russell Wilson makes his Giants debut with rookie Jaxson Dart waiting in the wings. He warned New York’s pass rush could trouble Daniels but still projected a 26-23 Commanders victory, trusting Eric Bieniemy’s offense to do just enough to cover at home.

Prisco laid 6.5 with Arizona, saying Jonathan Gannon’s defense "will be much improved" and should contain Spencer Rattler in his first NFL start. While conceding road openers are tricky, he expects the Cardinals’ revamped pass rush to limit explosive plays and escape 23-20. Bettors comfortable with Arizona’s defensive leap can still back them at anything under a touchdown.

Taking 2.5 points with Las Vegas, Prisco acknowledged the long East-coast trip but expects Pete Carroll to outfox Mike Vrabel in both coaches’ debuts. He trusts Geno Smith’s experience to edge a Patriots squad still installing Vrabel’s system. Prisco’s 24-23 scoreline makes the Raiders live on the moneyline and valuable against the spread.

Prisco laid 3.5 with Jacksonville, citing new head coach Liam Coen’s up-tempo scheme and a healthier Trevor Lawrence. He advised monitoring two-way weapon Travis Hunter but believes Lawrence will still be the difference versus Bryce Young. With the Panthers traveling and Coen’s play-calling "livening up" the Jags attack, Prisco forecast a 27-21 cover at home.

Backing Indy ‑1, Prisco highlighted Daniel Jones drawing a soft Miami corner group in his Colts debut while Tyreek Hill’s health keeps the total lofty. He sees both clubs trading chunk plays but trusts Jones to lean on Michael Pittman and Jonathan Taylor in a dome shootout. His projected 33-30 Indy win makes the near-pick’em price attractive for bettors who want exposure to a game he expects to clear 60 combined points.

Prisco laid 5.5 with Cincinnati, calling Joe Burrow versus Joe Flacco "a big edge" in the Battle of Ohio. He expects the Bengals offense to pick up where it left off in 2024, piling up yards even if Lou Anarumo’s defense still has questions. With Cleveland unlikely to match scores, Prisco projected a 30-27 final and recommended Cincinnati before bettors push the line to six or more.

Prisco laid the 2.5 with Tampa Bay, arguing Baker Mayfield is "ready for a big year" and should capitalize on lingering defensive holes Atlanta showed last season. Both clubs enter Sunday with banged-up offensive lines, but he trusts Mayfield more than Falcons newcomer Michael Penix Jr. to navigate the pressure. He forecast a 28-24 Bucs victory that nudges them toward controlling the NFC South race and makes Tampa the playable side under a field goal.

Prisco laid the 3.5 with Kansas City in Brazil, noting the Chiefs rebuilt offensive line held up all preseason while the Chargers lost left tackle Rashawn Slater for the year. He emphasized that giving Patrick Mahomes clean pockets is "a bad thing for a defense" and expects the former MVP to post big numbers right away. With L.A. shorthanded up front and forced to chase points, Prisco projected a 30-21 Chiefs win and advised backing K.C. before the number climbs past a field goal.