Ryan Wooden pinpointed Nick Castellanos as an excellent home run bet, emphasizing his elite performance against left-handed pitching (.528 career slugging, 8-for-16 this season) paired with extremely favorable hitting conditions that include 20 mph winds blowing out to left field on a warm day in St. Louis. Castellanos faces Cardinals starter Matthew Liberatore, who holds a concerning 5.84 ERA early on. Given Castellanos' historical strength against lefties and Liberatore struggling to limit damage, sportsbooks are offering tempting odds of +450 (FanDuel, BetMGM) for Castellanos to hit a home run.

Ryan Wooden strongly recommended betting on Marcell Ozuna to hit a home run against the Rays, citing ideal hitting conditions at George M. Steinbrenner Field after hurricane damage forced the Rays out of Tropicana Field. Ozuna, hitting with a 1.065 OPS so far this season with three homers, including one in the same ballpark two days prior, should benefit from the nearly 80-degree weather and strong winds blowing outwards. Furthermore, Ozuna historically hits right-handers and left-handers equally well, meaning he's set up nicely regardless of Rays' bullpen matchups. Both FanDuel and BetMGM offer value at +360 odds.

Ryan Wooden highlighted Pete Alonso as a strong candidate to homer against the Athletics, noting Alonso's hot start to the 2025 season with four home runs, 18 RBI, and a league-leading .714 slugging percentage. Alonso has traditionally punished right-handed pitching and faces Luis Severino, who has already allowed four home runs over his first three starts. The game will be played in warm conditions (78 degrees) with wind blowing across the field in Sacramento, factors that could further boost Alonso's home run chances. Wooden pointed out that Alonso already hit a homer Friday night in Sacramento, making him a compelling selection at +340 odds according to FanDuel Sportsbook.