Daniel Vreeland expressed confidence in Martin Perez's early-season form, noting Perez's excellent start to the year with only one run allowed through 12.1 innings along with 13 strikeouts. He expects Perez to continue his success against a Red Sox offense that has been average in generating first-inning runs. This strong pitching combined with Chicago's weak offense (ranked 24th in MLB in total runs scored) provides solid reasoning for an NRFI (No Run First Inning) wager for this game.

Lonte Smith sees value in backing Chicago White Sox in the first five innings, solely based on Martin Perez's superior recent form. Perez has allowed just one run across two starts, demonstrating swing-and-miss effectiveness. While recognizing Chicago's significant hitting struggles and overall poor performance (2-10 start, recently swept by Cleveland), Smith emphasized the temporary safety of backing Perez early to avoid the volatility of the White Sox lineup and bullpen over the full game. Smith suggested pairing the first five bet with the under total and considered a team total over for Boston post-Perez.

Eric Polzin recommended betting the under for Martin Perez's pitching fantasy score on PrizePicks. This decision factors heavily on Perez's low likelihood of achieving a quality start or win, critical components in PrizePicks' scoring model (wins count as 6 points, quality starts as 4 points). Polzin cited that Perez is at a minus-300 chance not to log a win according to Vegas sportsbooks, essentially removing those bonus points from consideration. Additionally, DraftKings set Perez's pitching outs line at 16.5 innings, clearly below the mark needed for a quality start (18 outs). Polzin explained that PrizePicks doesn't usually adjust these fantasy scores accordingly, resulting in advantageous betting edges. Thus, given Perez's realistic outcomes, Polzin strongly advises taking his fantasy scoring under.