Guy Boston likes Zach Littell and the Rays today at home against the Angels primarily due to pitching matchup concerns. Although Littell has had mixed early-season performances (impressing against Colorado but struggling unexpectedly against the low-powered Rangers offense), his best performance came at home. Boston noted Littell's heavy use of sliders, a pitch the Angels lineup historically struggles against. He also added that while Angels hitters do handle the splitter well, they perform poorly against sinkers and sliders overall and have not been impressive against right-handed pitchers generally. Despite recent Angels scoring trends, Boston remains skeptical of this line-up's true quality, offering a lean toward Tampa Bay as the better side to back at home.

Kenny G sees Zack Littell bouncing back after giving up five earned runs over seven innings, including a home run, in his previous outing against the Rangers. Though Littell (0-2, 4.15 ERA) struggled lately, Kenny believes the matchup against an Angels offense that's had inconsistencies presents a rebound opportunity. He pointed out the Rays bullpen's reliability, ranked around top 10 in MLB so far this season, and expects them to provide strong support for Littell when needed. Kenny also mentioned expecting regression from the Rays offense following their recent explosive performances, making it likely this game stays lower scoring, further supporting Littell to have an effective start.

Joel Bartilotta endorsed Zack Littell as a strong DFS pitching option against the Angels, highlighting Littell's consistency with a 3.80 ERA and 1.22 WHIP from 2023-2024, and even stronger home splits (3.27 ERA and 1.08 WHIP). Bartilotta pointed out Littell's previous success against the Angels, posting a 3.60 ERA and an impressive 9.9 K/9 rate in two appearances last season. The Angels were notably weak offensively, ranking among league-worst teams (27th or 28th) in runs, OBP, OPS, and xwOBA last year.

Eric Lindquist expresses skepticism towards Zack Littell despite his excellent seasonal debut, stating he had one of the better first outings possible. Still, Lindquist mentions Littell has been in MLB since 2018 as a middle reliever and hasn't demonstrated sustainable elite form historically. He suggests regression is possible against the Rangers, indicating Littell's very successful opening start may not reflect season-long growth or sustainability.

FanDuel has set Zack Littell's strikeout line at 4.5 Ks—with attractive odds (+102) for the over. Already having tallied 7 strikeouts in his lone start of 2025, Littell is demonstrating significant strikeout potential. Given his recent form and matchup against the Rangers' strikeout-friendly roster, betting over the 4.5 Ks line offers solid expected value.

Kyle Purviance recommends betting Zack Littell's strikeout prop over 5.5 at plus money against the Rockies. Purviance justified his optimism by referencing Littell's performance from last year, hitting 5 or more strikeouts in six of his first seven starts once he became a starter. He also pointed to Colorado's current lineup struggles, implying substantial difficulties generating offense, making them prime targets for strikeout-heavy pitchers and creating significant value on the Littell prop bet.