Davis Mattek said he "doesn’t want to pass" on Isaac Guerendo in the final rounds because the rookie owns an eye-popping 9.98 Relative Athletic Score and, in Mattek’s words, is "literally the most athletic running back in the NFL right now." Mattek is unbothered by fourth-rounder Jordan James, calling James "not good" and predicting Kyle Shanahan will lean on Guerendo’s 4.33 speed for explosive change-of-pace snaps behind Christian McCaffrey. With the 49ers annually top-10 in rush EPA and known for turning raw speed backs like Raheem Mostert and Elijah Mitchell into fantasy difference-makers, Mattek views Guerendo as a high-leverage final-round bullet whose ADP will rise once training-camp clips of long runs circulate.

Liam Murphy highlighted fourth-round rookie Isaac Guerendo as a must-mix final-round pick, noting the former Louisville back logged a 9.98 Relative Athletic Score that makes him "literally the most athletic running back in the NFL right now." Murphy is unfazed by Jordan James landing in the same backfield, calling James "not good" and emphasizing Kyle Shanahan’s history of turning raw speed backs (Mostert, Mitchell) into sudden fantasy factors. Guerendo’s 4.33 forty and 40-inch vertical translate to home-run Best Ball upside if Christian McCaffrey misses any time or Shanahan institutes another hot-hand rotation. Murphy prefers grabbing Guerendo before locking in a third quarterback, arguing the athletic profile gives drafters an asymmetric bet that can pay off in Week-15-to-17 tournament stages.