Davis Mattek called rookie Isaac Guerendo a "huge win" any time he lasts into the double-digit rounds, especially on rosters that fade Christian McCaffrey. Guerendo ran a blazing 4.33 forty at 221 lbs, giving him the second-best speed score in this year’s class and the same athletic profile that turned Elijah Mitchell into an immediate RB1 under Kyle Shanahan. Mattek noted the 49ers gave him a $255k guaranteed contract—more than Day-3 backs Tyler Allgeier or Elijah Mitchell received—signaling intent to keep him on the 53. With CMC entering age-28 territory and already nursing a heavy workload, Mattek thinks San Francisco will spell him more than people expect, opening a path to 8-10 weekly touches and a full-workhorse scenario if McCaffrey misses time. He prefers Guerendo over veteran handcuffs like Tyler Allgeier because the rookie’s ADP still sits outside the top-200 despite genuine league-winning upside.

Davis Mattek planted his Round-13 flag on Isaac Guerendo, calling the second-year back an "S-tier" handcuff who may still log 8–10 weekly touches even behind Christian McCaffrey. Mattek thinks San Francisco’s decision to flip Jordan Mason for a late pick signals real confidence in Guerendo as RB2. The former Louisville track star ran a 4.33 forty at 221 pounds and posted an 87th-percentile burst score— traits that mesh perfectly with Kyle Shanahan’s wide-zone scheme that led the NFL in rushing EPA per play last season. Mattek expects McCaffrey’s snap share to fall from 79 % to the low-70s in an effort to keep him fresh, projecting roughly 125 carries and 25 targets for Guerendo even without an injury. Should McCaffrey miss time, historical usage shows the backup averages 19.4 fantasy points per game under Shanahan (see 2020 Jeff Wilson stretch). At a back-half-of-Round-13 ADP, Mattek believes Guerendo belongs in the same conversation as Zach Charbonnet and Trey Benson, making him a must-click in Best Ball builds.

Billy Jones called Isaac Guerendo the ideal late-round swing when drafters have already locked in premium backs. San Francisco spent Day-3 capital and guaranteed money on the 221-pound 4.33-forty rookie, a clear signal the staff views him as Christian McCaffrey’s direct understudy. Jones emphasized that any McCaffrey injury would thrust Guerendo into Kyle Shanahan’s league-best RB environment—2023 backs in that role averaged 23.4 half-PPR points per start—instantly giving teams an every-down hammer without burning additional roster spots. Because the early trio of Barkley, Taylor and McCaffrey already supplies weekly floor, Jones wants Guerendo’s asymmetric upside and said he is comfortable stopping at four total running backs once he lands the rookie.

Davis Mattek said he "doesn’t want to pass" on Isaac Guerendo in the final rounds because the rookie owns an eye-popping 9.98 Relative Athletic Score and, in Mattek’s words, is "literally the most athletic running back in the NFL right now." Mattek is unbothered by fourth-rounder Jordan James, calling James "not good" and predicting Kyle Shanahan will lean on Guerendo’s 4.33 speed for explosive change-of-pace snaps behind Christian McCaffrey. With the 49ers annually top-10 in rush EPA and known for turning raw speed backs like Raheem Mostert and Elijah Mitchell into fantasy difference-makers, Mattek views Guerendo as a high-leverage final-round bullet whose ADP will rise once training-camp clips of long runs circulate.