Peter Appel strongly recommends betting on the Angels run line versus the White Sox, citing a significant starting pitching advantage favoring Los Angeles. He projects the Angels' probability of winning this game at 66.9%, justified by the gap between Jose Soriano's promising form and Jonathan Cannon's struggles. Despite Chicago's unexpected Opening Day win, Appel cautions bettors against overreacting. He notes the White Sox registered MLB's worst run line record last season (68-94) and encourages taking advantage of plus-money value currently available on the Angels' side, as he sees the betting market incorrectly influenced by earlier results.

Peter Appel advised betting against Jonathan Cannon, labeling him a clear fade candidate moving forward. Cannon had an unconvincing 2024 season, posting a below-average stat line characterized by low strikeout numbers and mediocrity in limiting walks. Lackluster spring training further highlighted his weaknesses, as he struck out just seven batters in 11.2 innings while surrendering 13 earned runs, walking three, and hitting three batters. Appel also noted Cannon's past early-season struggles—an ERA above 7.00 last April—and questioned the White Sox's continued reliance on him despite poor results in both MLB and Triple-A levels. Appel predicts a rough outing for Cannon against the Angels lineup.

Peter Appel recommended backing Jose Soriano against the White Sox due to a significant pitching mismatch. Soriano showed strong form down the stretch in 2024, posting a 2.45 ERA over 25 second-half innings along with increasing his strikeout rate to 23% and dropping his FIP from 4.12 to 2.74. Soriano's key strengths are his elite ground-ball rate—third-best among pitchers with over 110 innings last year—and his ability to induce swing-and-miss (30%+ whiff rate) with multiple off-speed pitches. His stuff looked even sharper in spring training, improving both strikeout and ground-ball metrics. Given projections that have the Angels winning the matchup approximately 66.9% of the time, Appel emphasizes Soriano as a pitcher worthy of trust until proven otherwise.