Matt LaMarca said Christian McCaffrey is an automatic cash-game spend-up at $7,500 on DraftKings after logging 22 carries and a 34% targets-per-route rate (30% team target share) in Week 1 while playing 75% of snaps. Even at a pedestrian 3.1 YPC, that usage translated to 23.2 DK points without a touchdown. LaMarca noted McCaffrey has averaged 23.94 DK points and a +6.0 Plus/Minus the 15 previous times he has been priced in this range. With Brock Purdy out and Mac Jones starting, LaMarca expects San Francisco to funnel even more rushes and back-field dump-offs to McCaffrey as three-point road favorites in New Orleans, giving him both the top median and ceiling projection plus the No. 1 projected Plus/Minus in FantasyLabs models.

Eric Moody identified Juwan Johnson as a tight-end streamer after he paced the Saints with eight catches for 76 yards against Arizona. Moody emphasized that Kellen Moore’s scheme funneled volume to Johnson and that Taysom Hill’s torn ACL removes a major snap-stealer near the goal line. Even in a tough matchup with the 49ers, Johnson’s expanded route tree and red-zone role make him a viable fantasy starter for managers scrambling at the position.

James Boutros advised betting Christian McCaffrey over 83.5 rushing yards (-110) because San Francisco’s offense is gutted and has no choice but to ride its star back. Brock Purdy and George Kittle are ruled out, Jauan Jennings hasn’t practiced, and Mac Jones will start at quarterback, all of which points to a ground-heavy script. Boutros reminded readers that McCaffrey already handled 22 carries in Week 1, while the Saints surrendered 146 rushing yards and a chunky 5.4 yards per carry to Arizona. With virtually every skill player around him sidelined, Boutros expects another 20-plus-carry afternoon that pushes McCaffrey comfortably past the prop line.

Even after the Brock Purdy injury news, MacMillan held his 49ers –6.5 (–108, FanDuel) ticket. He trusts Kyle Shanahan’s depth and coaching to overcome quarterback and tight-end injuries, especially against a Saints team he still ranks "worst in the league." He underscored Spencer Rattler’s 26th-place finish in EPA+CPOE composite in Week 1 as confirmation New Orleans lacks offensive punch, making a touchdown cover realistic for San Francisco.

DFS Army warned against loading up on Alvin Kamara despite strong model projections. The Saints project as frequent underdogs, and the tout emphasized a simple rule: "Don't play running backs on underdog teams that suck." Kamara’s fantasy value is touchdown-dependent; with New Orleans unlikely to reach the end zone often, he’ll post plenty of no-TD games that crater DFS lineups. DFS Army recommends fading popular Kamara chalk outside of large-field darts where low ownership compensates for the scoring risk.

DFS Army is "obsessed" with Christian McCaffrey again in Week 2, labeling him a value even at $7,500. The calf scare vanished once he logged 22 carries plus 10 targets (9 catches) in the opener, confirming true three-down usage. Against a New Orleans defense that has struggled to contain receiving backs, McCaffrey projects for both ground and air volume with minimal competition for touches—"Who else are they going to throw to?" DFS Army locked him in as a core cash-and-tournament play, expecting another 25-plus-touch outing.

Dave Loughran said to pounce on the 49ers –4.5 right now if you believe Brock Purdy will be cleared. He argued the number is mis-priced because books have partially baked in a potential Purdy absence. Loughran reminded listeners that Arizona closed –6.5 on the road in New Orleans last year and insists San Francisco is the superior roster compared to those Cardinals. Once confirmation on Purdy arrives he expects the spread to move at least a full point, giving early bettors closing-line value.

Dave Loughran told listeners to exploit the injury cloud over Brock Purdy. With George Kittle already out (the 49ers are 7-12 lifetime without him), Brandon Aiyuk sidelined, Jauan Jennings day-to-day and Purdy nursing multiple injuries, he believes the offense could crumble. If Purdy is ruled out, he wants the Saints +4.5 immediately, predicting the line will crash toward a field goal. Conversely, if you think Purdy guts it out, Loughran recommends locking in San Francisco now before the market corrects. Either way, the edge lies in acting before definitive news on Purdy’s status hits the books.