Guy Boston recommended betting Seattle as a plus-money underdog against San Francisco, primarily based on confidence in Brian Woo. Woo boasts great underlying numbers against Giants hitters (3.5% walk rate, 28% strikeout rate, .148 BA, .205 wOBA in 28 plate appearances). Despite Seattle historically struggling offensively (recently losing consecutive 10-9 games), he expects Woo to deliver a strong start at home, giving the Mariners good value. Additionally, Guy suggested a Nerfee bet thanks to Seattle's weak offense and Woo's strength matched-up versus Giants batters, plus Jordan Hicks's splits favorably limiting Seattle's predominantly right-handed lineup early in the game.

Bettor Mark enthusiastically identifies the first-five innings under 4 runs (-105) as one of his strongest plays of the day between Mariners and Giants, highlighting the outstanding pitching performances from starters Jordan Hicks (6 innings of standout work) and Bryan Woo (strong first outing). Although the Giants being 7-1 at home slightly concerns him, Mark maintains significant confidence in the pitchers suppressing offense early. He explicitly notes that if the game were in Seattle, this would qualify as a max bet. Nonetheless, even at San Francisco, he strongly endorses the first-five under as his best approach here.

JD Bets endorsed taking the San Francisco Giants moneyline, highlighting pitcher Jordan Hicks' impressive recent performance against the Astros, in which he allowed just one hit and recorded six strikeouts over six innings without giving up any runs. JD considered Hicks' ability to stifle a powerful Houston lineup as a significant indicator of his form and a clear advantage favoring San Francisco in their matchup with Seattle.

Dylan Rockford recommended betting the Mariners (+105), citing his numerical model that made Seattle slight favorites at -105 despite market prices. Rockford noted the Giants' recent four-game winning streak might lead to overconfidence and suggested a letdown spot could occur. He trusts Mariners starter Bryce Miller significantly more than San Francisco's Robbie Ray, who struggled previously this season against a weak Reds team. Additionally, Seattle hits lefties well, while the Giants have shown better success against lefties than righties. Altogether, these factors provided Rockford with clear value on Seattle as the underdog.

ESPN Fantasy cautioned fantasy managers considering Robbie Ray as a streamer on Saturday against the Mariners. Ray surrendered two home runs in his first start of the season against Cincinnati and has historically shown issues both with the long ball and issuing walks. Although Oracle Park typically suppresses home runs and thus mitigates power to a degree, the Mariners' lineup features league-average power coupled with a patient approach (high walk rate), both elements aligning problematic for Ray's persistent weaknesses. Managers looking to stream should proceed cautiously.

Data Skrive pointed out Heliot Ramos as a potentially lucrative home run prop bet (+560 odds) facing the Seattle Mariners. Ramos, somewhat flying under DFS radars, is benefiting from a sensational early-season power display, crushing 3 HR in just 7 games—a homer hit rate of a notable 42.9%. He presents an attractive combination of relatively favorable odds and strong recent slugging performances.

Data Skrive singled out Wilmer Flores as an excellent target for his home run prop bet against the Seattle Mariners, thanks to Flores' exceptional run of form. Flores has knocked 4 homers in just 7 games, hitting home runs at an impressive 57.1% rate, significantly higher than most other players. His current home run odds are listed at +830, providing enticing value considering his red-hot start at the plate.

Greg Peterson suggests betting on the Mariners (+115) and the over at 7 runs. Robbie Ray's recurring issues with walks and home runs (4 BB/9 and 2 HR/9 since joining San Francisco) should help awaken Seattle’s road lineup, which averaged nearly 4.6 runs away from T-Mobile Park last year. Mariners’ starter Bryce Miller had notable road struggles in 2024 (4.07 ERA and 1.6 HR/9), suggesting both offenses could be productive in San Francisco, further supporting a higher-scoring game than the line indicates.

Dylan Rockford advised strongly betting on Justin Verlander to surpass his strikeout total against Seattle, recommending laddering up to eight strikeouts. Verlander historically dominates the Mariners with a 22-10 career record, a 2.98 ERA, and approximately seven strikeouts per start against them. Given Seattle's consistent struggles to generate offense—scoring two or fewer runs in four of their seven games—Verlander's matchup is favorable. Rockford also supports betting on the Giants moneyline, citing their impressive recent form and overall team consistency.

MLBDream recommends betting the Giants team total over 3.5 runs for their game on April 4, 2025. The FTN MLB Model forecasts the Giants to score 4.23 runs, indicating a notable discrepancy. Given this projection, there's solid value in betting their total to exceed 3.5 runs at -145 odds offered by DraftKings, providing actionable wagering guidance backed by FTN's predictive models.

Cal Raleigh draws mention from Data Skrive as a sneaky solid play to homer against the Giants at +450 odds. Raleigh has hit just one homer so far in 7 games, but past track record and a 14.3% home run rate early in the season indicate he's capable of going deep at appealing odds.

Highlighting Wilmer Flores, Data Skrive emphasized his enormous value for home run bets at +900 odds. Flores has crushed home runs at a scorching pace, tallying 4 homers in his first 6 games, a homer rate of 66.7%—top in MLB early this season. Against Seattle's pitching, he presents an exceptional betting opportunity.

The Giants, with a strong early-season record of 5-1, are -148 moneyline favorites against the visiting Mariners (+123). Data Skrive's analysis favors San Francisco to secure the win at Oracle Park due to superior pitching in this matchup. Additionally, the game's total (8 runs) is projected to fall short, making the under bet appealing according to the computer picks.

Greg Peterson likes taking the Mariners ML (+132) against the Giants, handicapping it at +121. He points to Justin Verlander's declining effectiveness since 2024, evidenced by a 5.38 ERA and increased home run rate (1.5 per nine innings) at age 42. Seattle's improved road offensive numbers last year (4.6 runs/game) and starter Bryce Miller's breakout 2024 performance (2.98 ERA, 3.58 FIP, strong K-to-BB ratio) make the Mariners a savvy pick at the current price.